Smith-Cotton took an 18-15 lead into halftime but could not hold it, falling 30-29 to St. Pius X in a West Central Conference game on Friday in Kansas City.
St. Pius X outscored the Lady Tigers 9-6 in the fourth quarter to win.
Jack Greer led Smith-Cotton with nine points. Elena Sharp added seven and Abby Knight scored six.
Smith-Cotton (10-9, 2-2) will host Warrensburg on Friday.