Smith-Cotton fell to Hickman 17-5 in a nonconference baseball game on Thursday in Columbia.
The Kewpies scored six runs in the first inning, four in the third and seven in the fourth to end the game on the run rule.
Ian Dotson drove in three runs for the Tigers. Dalton Christian drove in two. Chance McMullin hit a pair of doubles.
Smith-Cotton (7-12) will visit Clinton for a West Central Conference game at 5 p.m. Friday.